Major depression has previously been associated with abnormalities in REM sleep. Excess REM sleep would diminish noradrenaline, resulting in decreased binding to the ɑ-2 receptor in the medial frontal lobes comprised of the ACC and the medial prefrontal cortex. The absence of REM sleep with TSD may give some participants a break to improve top-down control of the amygdala, resulting in an antidepressant effect.
One night of total sleep deprivation shown to have antidepressant effect for some people
https://medicalxpress.com/news/2023-07-night-total-deprivation-shown-antidepressant.html
1 Comments
grahamsz@kbin.social · 3 pts · 3y
If i'm reading that correctly, it was one night of sleep deprivation followed by one night of good sleep.
I've always found that the night after an all-nigher I sleep really well and wake up feeling pretty rested and good, but interesting to see that apparently only happens for some people.