This paper covers a potential causal link between cellular senescence and various aging phenotypes. Removing senescent cells exhibiting the kinase inhibitor and senescence biomarker p16 delayed the onset of age-related phenotypes in mouse skeletal muscle, adipose, and eye tissues.
[PAPER] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
https://pmc.ncbi.nlm.nih.gov/articles/PMC3468323/
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