In-universe & in-story very serious/emotional scenes that have lost considerable weight after being memed to death

"THINK, MARK, THINK" (Invincible): An epic clash of ideologies between two immortals, father and son

"NO NO NO WAIT WAIT WAIT" (The Punisher): Frank Castle watching his family killed in front of him

Walter White dramatically falling over (Breaking Bad): His reaction when Hank is killed

Willem Dafoe looking up at something (At Eternity's Gate): Vincent Van Gogh having a mental breakdown