Roadway to the Brain? Alzheimer’s Linked to Notorious Tire Chemical

https://studyfinds.com/alzheimers-disease-tire-chemical-6ppd-brain/

  • A tire chemical called 6PPD-Q, already blamed for killing salmon, was examined for possible links to Alzheimer’s disease in a new computer-based study.
  • Using computer models, researchers found that the chemical can latch onto several proteins associated with Alzheimer’s and reach brain regions involved in the disease.
  • No patients or animals were tested; the study rests entirely on computer predictions and reused datasets, so it cannot prove the chemical causes Alzheimer’s.
130 points · 13 comments · view on lemmy.world

13 Comments

LSNLDN@slrpnk.net · 19 pts · 52d

lol does this explain all the car brained people

randamumaki@lemmy.blahaj.zone · 8 pts · 52d

Welp, time to reinvent the wheel. cracks knuckles

psivchaz@reddthat.com · 7 pts · 52d (6 replies)

Interesting but I'm going to predict this goes nowhere. It doesn't look like the US has excessively high Alzheimers rates compared to countries that use less cars. The Netherlands still has plenty of Alzheimers diagnoses. I feel like you'd expect to see more regional variation if we could tie it to something like tires.

infinitesunrise@slrpnk.net · 7 pts · 52d

The Netherlands actually has one of the densest road networks in the world, and it's possible that the concentrations necessary for harm could be very low.

tyranny@crazypeople.online · 6 pts · 52d

from what I've heard, the Netherlands was a lot more car-based in the 1960s. is it possible that there is a delay to the difference in diagnoses?

apfelwoiSchoppen@lemmy.world · 3 pts · 52d (3 replies)

Bikes have vulcanized tires too.

infinitesunrise@slrpnk.net · 4 pts · 52d (1 reply)

Vulcanized

apfelwoiSchoppen@lemmy.world · 3 pts · 51d

Thanks for the correction, so edited. 🖖

phutatorius@lemmy.zip · 0 pts · 47d

Bike tires have less mass, accumulate much smaller mileage in a given time period, and are under far less mechanical stress than motor vehicle tires, so it's likely that they barely contribute to the overall shedding of these chemicals into the environment.

DarkCloud@lemmy.world · 2 pts · 52d (3 replies)

I'm seeing "computer models" and "computer predictions" but I'm reading 'AI'.

apfelwoiSchoppen@lemmy.world · 16 pts · 52d

Signal to noise detection in machine learning /= generative LLMs or agentic bullshit. This type of machine learning really does have a lot of application. It isn't what the AI industry is snake-oil selling cities to build data centers and murder our planet.

arctanthrope@lemmy.world · 8 pts · 52d

maybe, but AI systems used for scientific research are fundamentally different from the slop machines available to the public. they're designed for a single very specific purpose from a relevant dataset and the results are checked by experts; it's not just the entire internet regurgitated by an LLM and trained by a 22-year-old nepo-baby with an MBA

infinitesunrise@slrpnk.net · 3 pts · 52d

Then you've fallen for consumer marketing.