It’s a very funny joke. A white flag was literally their flag. It caused some issues when they tried to surrender and kept getting shot. So, they had to up their design game.
Recently published two-sample Mendelian randomization (MR) studies showed that genetically predicted coffee consumption may be associated with increased risk of Alzheimer’s disease and intracerebral hemorrhage but associated with a decreased risk of small vessel ischemic stroke. We aimed to investigate the effects of genetically predicted coffee consumption on magnetic resonance imaging (MRI) markers of cerebral small vessel disease and brain volume using the two-sample MR method.
Methods
Twelve single nucleotide polymorphisms (SNPs) in up to 375,833 individuals were used as genetic instruments for cups consumed per day of coffee. Another four SNPs from an independent sample were used to perform the replication analysis. Three SNPs in up to 45,821 individuals were used as genetic instruments for high coffee consumption vs. low/no coffee consumption.
Results
Mendelian randomization analysis showed that coffee consumption (cups/day) was inversely associated with gray matter volume (beta = −0.371, 95% CI = −0.596 to −0.147, p = 0.001). Replication analysis and multivariable analyses after adjusting for other risk factors confirmed the effect. High coffee consumption was also suggestively associated with decreased gray matter volume (beta = −0.061, 95% CI = −0.109 to −0.013, p = 0.013) compared with low/no coffee consumption. All analyses did not find an effect of coffee consumption on other outcomes including white matter hyperintensity volume, mean diffusivity, fractional anisotropy, brain microbleed, total brain volume, white matter volume, and hippocampus volume.
Conclusion
This two-sample MR study showed that genetically predicted higher coffee consumption is causally associated with reduced gray matter volume of the brain.
Modern thought refers to the intellectual and philosophical ideas that have emerged since the Renaissance and Enlightenment periods, continuing into the present day. It encompasses various fields, including science, philosophy, politics, and culture. Generally, modern thought values reason, individualism, empirical inquiry, and skepticism towards traditional authority. It has led to advancements in areas such as democracy, human rights, scientific method, and technological progress.
This is totally fascinating reading all the replies.
I love making bleeps and bloops using VCV rack and Mirack on iOS. The flexibility of modular synths in the digital realm is so much fun! And no one can do 5 minutes of conversation about it. Admittedly it’s pretty dense.
It’s a very funny joke. A white flag was literally their flag. It caused some issues when they tried to surrender and kept getting shot. So, they had to up their design game.
Wow, bulk downloading you rascal.
Here’s the summary:
Background
Recently published two-sample Mendelian randomization (MR) studies showed that genetically predicted coffee consumption may be associated with increased risk of Alzheimer’s disease and intracerebral hemorrhage but associated with a decreased risk of small vessel ischemic stroke. We aimed to investigate the effects of genetically predicted coffee consumption on magnetic resonance imaging (MRI) markers of cerebral small vessel disease and brain volume using the two-sample MR method.
Methods
Twelve single nucleotide polymorphisms (SNPs) in up to 375,833 individuals were used as genetic instruments for cups consumed per day of coffee. Another four SNPs from an independent sample were used to perform the replication analysis. Three SNPs in up to 45,821 individuals were used as genetic instruments for high coffee consumption vs. low/no coffee consumption.
Results
Mendelian randomization analysis showed that coffee consumption (cups/day) was inversely associated with gray matter volume (beta = −0.371, 95% CI = −0.596 to −0.147, p = 0.001). Replication analysis and multivariable analyses after adjusting for other risk factors confirmed the effect. High coffee consumption was also suggestively associated with decreased gray matter volume (beta = −0.061, 95% CI = −0.109 to −0.013, p = 0.013) compared with low/no coffee consumption. All analyses did not find an effect of coffee consumption on other outcomes including white matter hyperintensity volume, mean diffusivity, fractional anisotropy, brain microbleed, total brain volume, white matter volume, and hippocampus volume.
Conclusion
This two-sample MR study showed that genetically predicted higher coffee consumption is causally associated with reduced gray matter volume of the brain.
You would think a hijab is more sanitary than hair in a food service place.
We’ve had fun playing Elevenses, Odin’s Ravens, and Silver and Gold. Small, mostly card games but beautiful art and engaging gameplay.
Developers, developers, developers, developers, developers, developers, developers, developers, developers!
Here I am in the minority with strong chicory with heavy cream. All the bad breath; none of the drugs.
Oh boy are they unhinged.
Breathatarians intensify.
They call it the war of northern aggression. There “ain’t nothing civil about it”.
Hay, I see what you did there.
Thank you! I learned something today.
Hey thanks for introducing me to Midinous! That looks awesome. Yes, the sounds from VCV can border on industrial vibration at best.
And I’ve had the same fleeting dream of buying hardware, but who knows, indeed.
Chat GPT seems to think it’s:
Modern thought refers to the intellectual and philosophical ideas that have emerged since the Renaissance and Enlightenment periods, continuing into the present day. It encompasses various fields, including science, philosophy, politics, and culture. Generally, modern thought values reason, individualism, empirical inquiry, and skepticism towards traditional authority. It has led to advancements in areas such as democracy, human rights, scientific method, and technological progress.
What do you think it is?
Ah yes, Newsweek. The bastion of modern thought. /s
This is totally fascinating reading all the replies.
I love making bleeps and bloops using VCV rack and Mirack on iOS. The flexibility of modular synths in the digital realm is so much fun! And no one can do 5 minutes of conversation about it. Admittedly it’s pretty dense.
It looks like it’s in the basement.
I must be weird. I kinda like it. It keeps the grease and heat away from the rest of the prep space.
The creator of Soul Metal and the best mashup artist to grace this earth.
The intro lasts until 17:00.