Tylenol and alcohol are both processed through the liver and can harm it, especially when taken together, whereas ibuprofen ....
Okay I went to Wikipedia to check on the safety of ibuprofen with alcohol (bad idea, can cause gastric bleeding, just don't combine painkillers and booze in general) and I found out two (2) different things I found very interesting:
"Unlike most other NSAIDs, ibuprofen also acts as an inhibitor of Rho kinase and may be useful in recovery from spinal cord injury.[59][60] Another unusual activity is inhibition of the sweet taste receptor.[61]"
Hopefully I'll not need the first fact, but I'm all for anything that helps those who do.
And as a person with weight issues it's useful to me to know that second one so I don't sabotage myself!
Yeah that's a good call, definitely don't smash the ibuprofen, but I think one dose is generally pretty low risk, given I believe you still need to be overdosing on the ibuprofen to get problems, at least that's what a doctor told me when I asked a number of years ago.
The thing with alcohol and paracetamol/acetaminophen is it causes your liver to do something different than if you had the two separately. I'm not 100% I'm getting the terminology exactly right here but, If alcohol is taking up all of the "usual" enzyme a less efficient enzyme processes the paracetamol that's less efficient at metabolising it, that enzyme produces a toxic by-product that normally isn't created. That toxic by-product is what causes the liver failure if it can't subsequently be metabolised again quick enough.
A lot of things increase your risk of GI bleeding, it is a very serious danger but it's something you have to look at combinations of risk factors. I take high dose zoloft which increases my risk of GI bleeding and I drink socially, I never take more than a fairly low dose of ibuprofen or aspirin after drinking and I never take more than 200 mg of ibuprofen every 2 hours when not drinking, so far so good.
iirc the GI bleed risk is a standard NSAID thing. They cause your gastric and intestinal linings to grow slower, and since you need to constantly replenish that mucus. if it's not thick enough you get an ulcer.
standard not a doctor this isn't medical advice blahblah
The difference is that the intended/effective dose of Tylenol is shockingly close to the lethal one if you're taking it multiple times per day. It's a medication that would never have been approved for non-prescription use if it were discovered today.
Hot take: Americans don't know how dangerous this is. Every day I am reminded just how fucking dumb the average American is. A land of degrading intelligence. Our president loves the poorly educated, just like our elected officials do!
i'm afraid, our biggest concern should be a dangerous airborne chemical compound, called dioxygen. It spreads everywhere, and autism is on the mild side of possible effects caused by this lethal chemical weapon. I heard it even caused a great extinction once.
No, it wouldn't. These are likely 500mg pills, and there's 7 of them. That's 3.5g worth, well below the daily recommended limit of 4g and well below the 10g single dose limit for adults where toxicity becomes likely. Even if these were the chonky 1g pills, it's not likely to cause liver damage.
Depends on the concentration.
Yes Paracetamol can absolutely kill you if taken in grand excess. But this would have to be a very high dosage per pill to get you that far. Still not healthy of course.
38 Comments
artifex@piefed.social · 155 pts · 334d
Remember folks, taking too much Tylenol WILL destroy your liver and kill you fairly quickly.
9point6@lemmy.world · 63 pts · 334d
And don't take it the morning after a heavy night of drinking, it's like 10x more toxic in that scenario.
If you need a pain killer go for ibuprofen until like 24h after you finished your last drink
Battle_Masker@lemmy.blahaj.zone · 18 pts · 334d
Wait fr? Wtf
Mouselemming@sh.itjust.works · 26 pts · 334d
Tylenol and alcohol are both processed through the liver and can harm it, especially when taken together, whereas ibuprofen ....
Okay I went to Wikipedia to check on the safety of ibuprofen with alcohol (bad idea, can cause gastric bleeding, just don't combine painkillers and booze in general) and I found out two (2) different things I found very interesting:
"Unlike most other NSAIDs, ibuprofen also acts as an inhibitor of Rho kinase and may be useful in recovery from spinal cord injury.[59][60] Another unusual activity is inhibition of the sweet taste receptor.[61]"
Hopefully I'll not need the first fact, but I'm all for anything that helps those who do.
And as a person with weight issues it's useful to me to know that second one so I don't sabotage myself!
9point6@lemmy.world · 10 pts · 334d
Yeah that's a good call, definitely don't smash the ibuprofen, but I think one dose is generally pretty low risk, given I believe you still need to be overdosing on the ibuprofen to get problems, at least that's what a doctor told me when I asked a number of years ago.
The thing with alcohol and paracetamol/acetaminophen is it causes your liver to do something different than if you had the two separately. I'm not 100% I'm getting the terminology exactly right here but, If alcohol is taking up all of the "usual" enzyme a less efficient enzyme processes the paracetamol that's less efficient at metabolising it, that enzyme produces a toxic by-product that normally isn't created. That toxic by-product is what causes the liver failure if it can't subsequently be metabolised again quick enough.
kerrigan778@lemmy.blahaj.zone · 4 pts · 334d
A lot of things increase your risk of GI bleeding, it is a very serious danger but it's something you have to look at combinations of risk factors. I take high dose zoloft which increases my risk of GI bleeding and I drink socially, I never take more than a fairly low dose of ibuprofen or aspirin after drinking and I never take more than 200 mg of ibuprofen every 2 hours when not drinking, so far so good.
HeyThisIsntTheYMCA@lemmy.world · 3 pts · 333d
iirc the GI bleed risk is a standard NSAID thing. They cause your gastric and intestinal linings to grow slower, and since you need to constantly replenish that mucus. if it's not thick enough you get an ulcer.
standard not a doctor this isn't medical advice blahblah
Swedneck@discuss.tchncs.de · 1 pts · 320d
i have an even better recommendation there: don't drink enough to get a hangover, ever.
jaybone@lemmy.zip · 8 pts · 334d
It can damage your liver. Though some say it is greatly exaggerated when this discussion pops up online. But still I wouldn’t risk it.
I think advil/motrin is a safer NSAID if you are a drinker.
WillStealYourUsername@piefed.blahaj.zone · 40 pts · 334d
Liver failure is a fairly slow death taking up to a month
artifex@piefed.social · 20 pts · 334d
Ok I didn’t mean like gunshot quick more like “get your affairs in order” quick.
mic_check_one_two@lemmy.dbzer0.com · 28 pts · 334d
Correction: It will start killing you quickly, but the actual death will be long and painful. Liver failure is a particularly bad way to go out.
fuckgod@feddit.online · 6 pts · 334d
Man, Trump looks like he could use a night out drinking and then hangover relief with Tylenol.
criss_cross@lemmy.world · 14 pts · 334d
My favorite stat about the safety seals is that you’re much more likely to die taking Tylenol than from someone poisoning your Tylenol.
latenightnoir@lemmy.blahaj.zone · 9 pts · 334d
Is that a threat, or a promise?😏😏
Zizzy@lemmy.blahaj.zone · 15 pts · 334d
Its really painful and not quick.
latenightnoir@lemmy.blahaj.zone · 4 pts · 334d
Question still stands:))
Cevilia@lemmy.blahaj.zone · 3 pts · 333d
latenightnoir@lemmy.blahaj.zone · 0 pts · 333d
Really gotta stop with this kinky talk, doin' me no good:))
Midnitte@beehaw.org · 4 pts · 334d
As will corn, chocolate, and water.
Quetzalcutlass@lemmy.world · 1 pts · 333d
The difference is that the intended/effective dose of Tylenol is shockingly close to the lethal one if you're taking it multiple times per day. It's a medication that would never have been approved for non-prescription use if it were discovered today.
MML@sh.itjust.works · 4 pts · 333d
Take ibuprofen instead and destroy your intestines instead!
QuinnyCoded@sh.itjust.works · 2 pts · 332d
Zoomboingding@lemmy.world · 38 pts · 334d
Yeah this is a joke I can't get behind because not everyone knows how dangerous this is
OldChicoAle@lemmy.world · 11 pts · 334d
Hot take: Americans don't know how dangerous this is. Every day I am reminded just how fucking dumb the average American is. A land of degrading intelligence. Our president loves the poorly educated, just like our elected officials do!
BadJojo@lemmy.blahaj.zone · 27 pts · 334d
So many layers to this joke, and they are all now federal crimes.
CheesyFox@lemmy.sdf.org · 10 pts · 333d
this joke is too american for me to understand
WillStealYourUsername@piefed.blahaj.zone · 13 pts · 333d
Doctors and scientists in my country assured everyone that paracetamol (tylenol) is fine and to ignore whatever the US is doing :P
But for your information Trump announced that paracetamol during pregnancy causes autism.
CheesyFox@lemmy.sdf.org · 6 pts · 333d
ah, i see, another day, another cause of autism. What a fucking clown.
OrteilGenou@lemmy.world · 4 pts · 333d
Clowns are another cause of autism, probably
CheesyFox@lemmy.sdf.org · 2 pts · 333d
i'm afraid, our biggest concern should be a dangerous airborne chemical compound, called dioxygen. It spreads everywhere, and autism is on the mild side of possible effects caused by this lethal chemical weapon. I heard it even caused a great extinction once.
StrixUralensis@tarte.nuage-libre.fr · 8 pts · 334d
Username checks out
EffortlessEffluvium@lemmy.zip · 5 pts · 334d
You wanna give that kid autism!?!
cupcakezealot@piefed.blahaj.zone · 4 pts · 333d
they're shaped like mini bomb pops so they have to be good
Geodad@lemmy.world · 0 pts · 333d
ChairmanMeow@programming.dev · 12 pts · 333d
No, it wouldn't. These are likely 500mg pills, and there's 7 of them. That's 3.5g worth, well below the daily recommended limit of 4g and well below the 10g single dose limit for adults where toxicity becomes likely. Even if these were the chonky 1g pills, it's not likely to cause liver damage.
Phineaz@feddit.org · 2 pts · 333d
Depends on the concentration. Yes Paracetamol can absolutely kill you if taken in grand excess. But this would have to be a very high dosage per pill to get you that far. Still not healthy of course.
DragonTypeWyvern@midwest.social · -2 pts · 333d
Lol no
Geodad@lemmy.world · -3 pts · 333d
OrteilGenou@lemmy.world · 2 pts · 333d
No, this is a hyper autistic dose, but it won't cause death unless there's a bible nearby
DragonTypeWyvern@midwest.social · -1 pts · 333d
If that makes you feel better