Level9831

u/Level9831@lemmy.world
2 posts · 35 comments

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I spend about $200/month just for myself. I cook breakfast, lunch, and dinner. Take lunch with me to work everyday. I eat very very plain food (ie rice and chicken every day). With grocery prices up, I cut out a lot from my diet to keep around $200/month. No beef, no fresh fish, no fruits, no yogurt/kefir.

Meat: chicken, turkey, tuna fish, eggs and egg whites Veggies: kale, collard green, frozen veggies, tomatoes Carbs: rice, pasta, sweet potato, canned beans, peanut butter, granola bars, cereal Fruit: I admit I bought a bag of apples recently Dairy: milk, mozzarella cheese

I go to the gym regularly and drink 1-2 protein shakes per day.

Kind of embarrassing that I live on such a restricted boring diet, but at least I cook for myself, stay within budget, and stay away from processed foods/ snacks.

Differences: N-acetylcysteine is formulated as both IV or inhalation solutions, whereas the effervescent formulation (brand name Legubeti, FDA approved Feb 2024) is given as an oral solution. According to the prescribing information, Legubeti active ingredient is actually acetylcysteine lysine, but is still dosed based on acetylcysteine. Dosing is technically not an exact conversation (4.74 g of acetylcysteine lysine = 2.5 g acetylcysteine), however, clinically, we are always dosing based on acetylcysteine. It appears to be manufactured in two strengths 500mg and 2.5 g (acetylcysteine content).

Tldr: nac or acetylcysteine lysine --->convert to acetylcysteine. We always dose based on acetylcysteine. The effervescent is specifically formulated for PO administration and indicated for acetaminophen OD.

Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren't usually prescribed together.

Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.

Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]

on *Permanently Deleted* · c/asklemmy · 8 pts · 1y

Hi, pharmacist here. I wanted to clarify that the "discontinuation" you saw on the FDA website regarding sertraline does not mean the drug has been taken off the market. It simply indicates that one manufacturer—Strides Pharma Inc.—has recently stopped producing all strengths of sertraline tablets (25 mg, 50 mg, and 100 mg).

Sertraline is a widely used generic medication, and many other manufacturers continue to produce it.