Salient points for those who don’t want to read the article, or can’t:
The team administered a single shot of E. americana intravenously to mice with colorectal cancer, and it completely eliminated tumors in every treated animal.
Caused only short-lived inflammatory effects that resolved within 72 hours
Over two months of observation, treated mice showed no signs of organ damage or chronic toxicity.
The bacterium are also sensitive to antibiotics, providing intervention options if problems were to arise following treatment.
When the mice were later re-exposed to cancer cells, none developed new tumors, suggesting the treatment had triggered long-lasting immune memory.
This holds some real promise, I’m very excited to see what this brings! Kudos to the researchers!
What's more, the response wasn’t just rapid but appeared to provide ongoing protection. When the mice were later re-exposed to cancer cells, none developed new tumors
first, it has a natural affinity for the low-oxygen environment inside solid tumors, so within just 24 hours it had increased its numbers by around 3,000-fold, but it also didn't drift over to impact any other healthy organs or tissue. Then it's able to directly kill the growth thanks to toxins it secretes inside the tumor.
At the same time, the bacterial invasion triggered a natural immune response, and the tumors soon became flooded with immune cells – particularly neutrophils, and T and B cells – alongside increases in inflammatory signaling molecules. The combined effect was widespread tumor cell death driven both by direct bacterial action from the foreign gut bug and by the host’s own immune system.
...
Importantly, this mechanism appears to also be highly tumor-specific, with E. americana sticking only to the tumor environment. The researchers believe this selectivity arises from a combination of factors unique to tumors – insufficient oxygen (hypoxia), leaky blood vessels, altered metabolism and locally suppressed immune defenses that allow the bacterial colony to thrive where they are also most destructive.
Could be we just aren't eating enough uncooked whole, live frogs in our modern diet. Someone has to volunteer to gulp down a few to see if their probiotics cure their cancer, throw some newts in for good measure. If we don't get proof that works at a citizen science level, pharma companies will at best brew the bacteria in a lab and sell it back to us at exorbitant prices. Who will be the next Jonas Salk?
43 Comments
KingOfSuede@lemmy.world · 167 pts · 244d
Salient points for those who don’t want to read the article, or can’t:
The team administered a single shot of E. americana intravenously to mice with colorectal cancer, and it completely eliminated tumors in every treated animal.
Caused only short-lived inflammatory effects that resolved within 72 hours
Over two months of observation, treated mice showed no signs of organ damage or chronic toxicity.
The bacterium are also sensitive to antibiotics, providing intervention options if problems were to arise following treatment.
When the mice were later re-exposed to cancer cells, none developed new tumors, suggesting the treatment had triggered long-lasting immune memory.
This holds some real promise, I’m very excited to see what this brings! Kudos to the researchers!
UltraBlack@lemmy.world · 18 pts · 244d
Mfw bacteria become resistant: 😱😱😱
BuboScandiacus@mander.xyz · 13 pts · 244d
Still probably better than cancer, no ?
musubibreakfast@lemmy.world · 6 pts · 243d
Yes, now you have to shove a live frog up your ass every day or die of colon cancer.
UltraBlack@lemmy.world · 3 pts · 243d
Multiresistant bacteria are a death sentence in many cases...
IAmNorRealTakeYourMeds@lemmy.world · 2 pts · 243d
and cancer isn't?
acockworkorange@mander.xyz · 1 pts · 243d
In many cases it isn't.
RVGamer06@sh.itjust.works · 2 pts · 243d
Le epic bacteriophage:
zakobjoa@lemmy.world · 65 pts · 244d
Just a minute at 2000°C also eliminated all cancer cells in mice.
First_Thunder@lemmy.zip · 41 pts · 244d
Impact on the remaining cells still requires further studying
Test_Tickles@lemmy.world · 21 pts · 244d
It turns out that the witch who turned the prince into a frog was actually curing his cancer not cursing him.
BootLoop@sh.itjust.works · 2 pts · 243d
That is outside of the scope of this study however.
MonkderVierte@lemmy.zip · 23 pts · 244d
But no immune memory.
bdonvr@thelemmy.club · 9 pts · 244d
Did we read the same paper? Not a single case of regression after treatment.
XM34@feddit.org · 5 pts · 244d
They were talking about the downsides of treatment via 2000 °C.
bdonvr@thelemmy.club · 5 pts · 244d
Yeah so was I. But they're wrong, like I said no specimen had cancer return after the 2000⁰C treatment.
jmill@lemmy.zip · 3 pts · 244d
True, but by a different mechanism. Immune memory was not involved in their continued resistance.
MonkderVierte@lemmy.zip · 1 pts · 244d
Yes, this.
IAmNorRealTakeYourMeds@lemmy.world · 4 pts · 243d
oh, the immune system will remember, all your cells will remember
TypFaffke@feddit.org · 21 pts · 244d
Ah yes, Thermotherapy
Engywuck@lemmy.zip · 1 pts · 244d
I bet I can do the same in under 10 s.
RacerX@lemmy.zip · 25 pts · 244d
Awesome!
... we'll never hear about this again.
Konstant@lemmy.world · 23 pts · 244d
Getting news from memes is next level.
lurch@sh.itjust.works · 21 pts · 244d
afraid to ask: did it also eliminate the mice?
ElderReflections@fedia.io · 43 pts · 244d
Apparently it made them stronger
ShinkanTrain@lemmy.ml · 19 pts · 244d
Please stop praying for my mice, they've become too strong. One of them chewed through the fridge
Manjushri@piefed.social · 7 pts · 244d
Quite the contrary...
...
untorquer@lemmy.world · 2 pts · 243d
Shit thats a lot of promising routes of action and modulation.
Deestan@lemmy.world · 20 pts · 244d
https://xkcd.com/1217/
ShinkanTrain@lemmy.ml · 10 pts · 244d
How do you administer handgun for colon cancer? 😳
Deestan@lemmy.world · 7 pts · 244d
You shouldn't. The side effects turn out to usually be more harmful than the cancer.
BuboScandiacus@mander.xyz · 4 pts · 244d
Skill issue
SaharaMaleikuhm@feddit.org · 13 pts · 244d
Do I eat frog poop or should I suckle on their anus for best results?
falseWhite@lemmy.world · 12 pts · 244d
pewpew@feddit.it · 1 pts · 244d
Neither. Vore time
shalafi@lemmy.world · 9 pts · 243d
This is my argument for government science budgets.
Headline: Scientists Spend Millions Studying Andean Frog Fucking Habits!
"What a waste!"
What if I told you those scientists were making more frogs to study how they can freeze solid and thaw out? Or how limb regeneration works?
IAmNorRealTakeYourMeds@lemmy.world · 8 pts · 243d
Practically all meds come from science like that.
why are you studying Easter island soil? discovery of Rapamicin and the cell cenesense pathways in human cells.
Luvs2Spuj@lemmy.world · 9 pts · 244d
If this takes off it could be a great thing for conservation. Frogs are in a lot of trouble!
Sadly I'm not so sure, but I like to be optimistic
untorquer@lemmy.world · 3 pts · 243d
Leaps off
West_of_West@piefed.social · 7 pts · 244d
Gale: Stop licking the damn thing!
NigelFrobisher@aussie.zone · 4 pts · 243d
They needn’t worry unless the mouse experimental animal Union is more powerful than theirs.
thenewred@lemmy.world · 1 pts · 244d
:bufo-offers-gut-bacterium:
Asidonhopo@lemmy.world · 1 pts · 242d
Could be we just aren't eating enough uncooked whole, live frogs in our modern diet. Someone has to volunteer to gulp down a few to see if their probiotics cure their cancer, throw some newts in for good measure. If we don't get proof that works at a citizen science level, pharma companies will at best brew the bacteria in a lab and sell it back to us at exorbitant prices. Who will be the next Jonas Salk?
robocall@lemmy.world · 1 pts · 243d
I am down to get some frog gut shots