Study suggests shingles vaccine may lower dementia risk

https://www.brown.edu/news/2026-06-15/shingles-vaccine-lowers-dementia-risk

161 points · 17 comments · view on lemmy.world

17 Comments

BarneyPiccolo@lemmy.today · 23 pts · 44d (4 replies)

I was sweating the Shingles shots (it's 2 shots, 2 months apart), because I didn't want to get shingles, and kick myself the entire time for procrastinating. When I walked out after the second shot, knowing I was protected, I actually felt good.

Now it's helping against dementia, too? Awesome.

altphoto@lemmy.today · 5 pts · 44d (3 replies)

I can't get it because I'm too old now.

albbi@piefed.ca · 7 pts · 44d (2 replies)

Weird, all information about the shingles vaccine I've seen just says 50 or older.

corsicanguppy@lemmy.ca · 4 pts · 44d (1 reply)

In Canada, if you're over 50, it's apparently free-to-you with your continuing yearly subscription to our government as a bundle.

SaveTheTuaHawk@lemmy.ca · 2 pts · 43d

Over 65. Not 50.

kaklerbitmap@lemmy.world · 6 pts · 44d (4 replies)

Is there a point to getting the shingles vaccine if you've already had an outbreak of it? I had it in my 20's but I'm approaching 50 now

MyTurtleSwimsUpsideDown@fedia.io · 10 pts · 44d
comador@lemmy.world · 7 pts · 43d

Imagine how it felt having it in your 20s and now imagine having it at 70+.

At 50 you know by now you don't heal or recover from colds as fast as you did at 20, so getting the shingles vaccine between now and 60 is basically insurance against feeling that ever again.

corsicanguppy@lemmy.ca · 4 pts · 44d

Man I hope so. I got it at like 25 but I did the shinrix a few years ago just so I don't get it again. Yeesh, but that sucked.

SaveTheTuaHawk@lemmy.ca · 3 pts · 43d

Herpes zoster does not go away after infection, it reservoirs in the nervous system, constantly controlled by the immune response. In older people or immune compromised, this immunity wanes. That's why you need Shingrex when over 65.

Entertainmeonly@lemmy.blahaj.zone · 2 pts · 44d (5 replies)

For some reason i think of the myth that got spread around about wine being healthy for your heart. Are we sure it's not just a correlation that people who get the vaccine tend to be in a better position to stay healthy than those that may not be able to or refuse the vaccine?

Edit: just to be clear i agree the vaccine is awesome.

CompactFlax@discuss.tchncs.de · 14 pts · 44d

Shingles is a herpes. Other herpes viruses are also linked to dementia. It’s probably not a coincidence.

bluGill@fedia.io · 11 pts · 44d (1 reply)

As my doctor said when she said I should get the vaccine: If this study is true, it's great it great, but even if this study turns out to be false, it doesn't matter because I should get the vaccine anyway.

SaveTheTuaHawk@lemmy.ca · 2 pts · 43d

There are half a dozen studies with the same conclusions. The best was in UK, where because of some stupid rule, people born a week later could not get Shingrex, so they ended up with a huge control population. Interestingly, the protective effect is only seen in women.

But other studies show protection effects from all vaccines in elderly.

psud@aussie.zone · 1 pts · 39d

Wine being healthy was from epidemiology - the sort of study that sends out tens of thousands of food frequency questionnaires asking people to detail what categories of food each participant ate over the prior 5 years.

All it really said is the kind of person who says they have 1 glass of wine each day is healthier than the kind of person who says they have none

An earlier similar study was done that said people who claimed to consume eggs had worse heart health. This one was tested later by a controlled trial where people were told to eat or not eat eggs. That study found eggs were protective against heart disease.

SaveTheTuaHawk@lemmy.ca · 1 pts · 43d

No, there is actual mechanism here, and it's not just shingles vaccine. Older people who get frequent vaccinations have lower incidence of Alzheimer's. The reason is that infection causes a strong immune response that releases a lot of reactive oxygen species. In young people, their mitochondria can deal with this, but in older people mitochondria don't work as well and brains get more oxidative damage. Zoster is just a virus more prevalent in neurons.

The one fact buried in the Shingrex effect is that it appears to occur in women only.

Scotty_Trees@lemmy.world · 1 pts · 43d

"may" Okay 👀️