In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.
Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649
53 Comments
NoTagBacks@lemmy.dbzer0.com · 110 pts · 230d
Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.
FlashMobOfOne@lemmy.world · 29 pts · 230d
This summer we'll find out the results of the Galleri test trials in the UK. Another game changer potentially.
veroxii@aussie.zone · 17 pts · 230d
Would've been useful before I had my foot cut off. 🤷♂️
ChairmanMeow@programming.dev · 22 pts · 230d
In 20 years you'll get a pill from the pharmacy to grow a new one 😋
Maeve@kbin.earth · 7 pts · 230d
Depends on affordability.
87Six@lemmy.zip · 13 pts · 230d
TONIGHT ON DEAL OR NO DEAL:
you can get this new leg but it will cost you a kidney
MrShankles@reddthat.com · 7 pts · 230d
I only need one kidney, AND I can have 3 legs. Deal
Hazy@aussie.zone · 2 pts · 230d
I already have 3 😏
Sciaphobia@sh.itjust.works · 1 pts · 230d
But you have to rename yourself Toejam and befriend someone named Earl.
ChairmanMeow@programming.dev · 6 pts · 230d
It might cost you an arm and a leg.
Kirp123@lemmy.world · 5 pts · 230d
That means you don't need your cartilage regrown.
Lemmyoutofhere@lemmy.ca · 55 pts · 230d
As a 50+ year old mechanic, this can’t come soon enough.
chonglibloodsport@lemmy.world · 20 pts · 230d
Wow yes. So many older and retired workers from the skilled trades could benefit from this.
It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.
Damage@feddit.it · 5 pts · 230d
Arthritis is not limited to trade workers, anyone can have it.
And it isn't the only health issue physical work can cause.
roofuskit@lemmy.world · 12 pts · 230d
Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.
explodicle@sh.itjust.works · 10 pts · 230d
Honestly I'd take that over this arthritis
stringere@sh.itjust.works · 2 pts · 230d
It's in my mouse clicker finger and starting to make video game controllers uncomfortable. Make it stop!
cyberpunk007@lemmy.ca · 4 pts · 230d
Uhg. Sad reality.
Dupelet@piefed.social · 3 pts · 230d
Or move outside the US
roofuskit@lemmy.world · 1 pts · 230d
Or win the lottery.
angrystego@lemmy.world · 2 pts · 230d
I don't think arthritis is the win you think it is.
SaveTheTuaHawk@lemmy.ca · 9 pts · 230d
Spoiler alert: you can't afford it.
Dupelet@piefed.social · 8 pts · 230d
Speak for the Americans. The rest of us have no trouble doing so
rumba@lemmy.zip · 7 pts · 230d
also cancer :)
Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C
Lemmyoutofhere@lemmy.ca · -1 pts · 230d
Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.
rumba@lemmy.zip · 2 pts · 230d
Not in this case.
"Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer."
https://www.hsci.harvard.edu/stem-cells-and-cancer
Lemmar@lemmy.today · 2 pts · 229d
The news article, as well as the published work, state that:
Long-term side effects will need to researched of course and there might still be stem cells involved in the process, however that doesn't seem to be the case according to what we know as of now.
rumba@lemmy.zip · 1 pts · 229d
I will gladly throw it on top of my monstrous pile of promising-looking research in hopes that it becomes a successful procedure.
hanrahan@piefed.social · 8 pts · 230d
Thank you for doing useful work
Mac@mander.xyz · 31 pts · 230d
The rich are going to live well
Dupelet@piefed.social · 25 pts · 230d
So are non Americans
popekingjoe@lemmy.world · 28 pts · 230d
SkunkWorkz@lemmy.world · 21 pts · 230d
Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.
musubibreakfast@lemmy.world · 3 pts · 230d
"I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!"
Lemmar@lemmy.today · 1 pts · 229d
Most definitely. I'm almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.
If this gets proven to work in vivo in humans I'm certain we'll see the same no matter side effects.
blarghly@lemmy.world · 1 pts · 227d
I've also heard the peptide hype. I'm curious, as an aging athletic person - but also I don't want to roll the dice with cancer
Grandwolf319@sh.itjust.works · 16 pts · 230d
Between this and growing new teeth, things are looking a lot more cyberpunk than before.
Lawnman23@lemmy.world · 8 pts · 230d
Waraugh@lemmy.dbzer0.com · 2 pts · 230d
Is that from a game? Kind of looks like Keanu Reeves
Damage@feddit.it · 6 pts · 230d
Cyberpunk 2077, and yeah, it's Keanu Reeves as Johnny Silverhand.
They've got Idris Elba too in the DLC.
Grandwolf319@sh.itjust.works · 4 pts · 230d
Yes and yes.
Cyberpunk 77
Sharkticon@lemmy.zip · 6 pts · 230d
In that only the upper wealthy class will be able to afford it?
Smoogs@lemmy.world · 15 pts · 230d
So…there’s a chance I can back into martial arts? Bring it.
stringere@sh.itjust.works · 6 pts · 230d
Martial arts should probably be approached from the front, but you do you, boo.
wabafee@lemmy.world · 7 pts · 230d
Damn mice's at this point they will reach immortality first. Then again thankful for that lol.
pulsewidth@lemmy.world · 8 pts · 230d
They'll deserve it, the shit we've put them through.
I feel there's very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse
charade_you_are@sh.itjust.works · 7 pts · 230d
What the fuck? All we ever needed was a pill? Is everybody stupid?
Hupf@feddit.org · 3 pts · 230d
https://youtu.be/Ssq8wHAx4nE
HurricaneLiz@lemmy.world · 1 pts · 230d
Haahaha 😂
SocialMediaRefugee@lemmy.world · 5 pts · 230d
I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.
SocialMediaRefugee@lemmy.world · 3 pts · 230d
The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"
I found this:
So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.
Taleya@aussie.zone · 2 pts · 230d
reproductive urge, you mean.
Plenty of women with the equipment and no intention of using it.
angrystego@lemmy.world · 4 pts · 230d
Well, that's part of what you'd have to consider. The reply didn't state it would be contraindicated in reproductive age, just that it shouldn't be applied without consideration.