We justify the expenditure in this study with the need to repeat the experiment up to 500 times to reach statistical significance.
The ethics committee approved the project after testing the sample of preliminary evidence we provided them with.
The animal welfare committee has concluded the most humane way to coke up the fish is for the researchers to also do a few bumps so they feel like it's a party.
Is the Swedish study that tested cocaine in salmon and found the cocaine fish swam further than sober fish but both swam less than the salmon who ingested metabolized cocaine surprisingly swam the furthest. This is important because it shows human drug use is screwing up nature. The metabolized cocaine is benzoylecgonine found in human urine and it is being absorbed by the fish. It's super interesting to see how even on dry land humans can change the sea without trying.
Are people really using enough cocaine that its impact on the ocean is significant? Like Iโm guessing a lot of people drive a car, which Iโm guessing is a lot worse than cocaine.
Benzoylecgonine is very stable. It can in fact be analyzed in tap water in communities that recycle waste water to determine how much cocaine is being used.
Indeed, but it is a fair question to ask: what is the actual concentration in the ocean? I did not read the study, possibly they used a concentration similar to the one encountered in oceans.
Seeing as this is about salmon, it's probably more relevant to ask about the concentration in rivers. A river downstream from a reasonable size city likely has a not insignificant level. I assume the ocean is effectively nothing though.
This was actually a really good study. While cocaine certainly fucks them up, it's actually the human-cocaine metabolite that's more impactful! So, ya know, we gotta make sure we're doing waste water treatment so as to not fuck over the fish from the Saturday night, town-wide benders y'all keep having.
Coke and meth are similar in that they both activate stimulate Dopamine (reward, motivation), Norepinephrine (arousal, alertness) Serotonin (mood, modulation).
However they do it in very different ways:
Cocaine blocks neurotransmitter reuptake from the outside, it stops the neurotransmitter from being released from the synapse causing the area to flood and the synapse to fire more strongly, but still tied to normal stimulation. I.e. your body still produces the transmitter based on normal stimuli, coke just keeps it there longer, stretching the existing signal.
Methamphetamine drives release from the inside. It pushes dopamine out and into the synapse, and has some reuptake inhibition that combines drive the synapses far harder than normal. In contrast to coke, it doesn't stretch existing signals from physiological stimuli, it makes signals regardless of what's going on.
In short, coke blocks the sink's drain. Meth turns on the tap and sorta plugs the drain. Slight advantage to meth here for ADHD. CNS depression that underlies it responds better to meth because the taps don't open enough to begin with. Normal psysiological stimuli isn't enough.
Both in theory could treat ADHD, but meth wins by a longshot because of the speed and stability of its pharmacokinetics. Coke is in and out too fast to give the user the therapeutic window of relief without causing spikes that trigger negatives like addiction or heart problems. Meth is slower and longer lasting. 20-60 mins for coke, ~4 hours for meth. Leveraging extended release (er) formulations pushes meths already superior action (turn on tap) into a daily therapeutic window, while coke is still just behaving like a party drug.
Source: Lots of personal research. ( อกยฐ อส อกยฐ)
I learned the cocaine thing the second time I tried it (first was just a bump at new years that kept me from getting drunk).
My friends were bouncing off the walls having a great time while I sat there and tripled my high score in Snake. I remember thinking, "this is like a shitty Adderall."
I heard that they were trying to get the WHO to decriminalise coca leaf. Would be great if a cup of tea could replace a controlled substance for ADHD treatment. More research needed ofc but hey, it's hopeful
Some days ago there was literally an article about this shared around here that says the coked up salmon are swimming for longer and further for their mating season.
24 Comments
ranzispa@mander.xyz · 35 pts · 137d
Grant proposal:
We justify the expenditure in this study with the need to repeat the experiment up to 500 times to reach statistical significance. The ethics committee approved the project after testing the sample of preliminary evidence we provided them with.
turtlesareneat@piefed.ca · 12 pts · 137d
The animal welfare committee has concluded the most humane way to coke up the fish is for the researchers to also do a few bumps so they feel like it's a party.
ChicoSuave@lemmy.world · 29 pts · 137d
Is the Swedish study that tested cocaine in salmon and found the cocaine fish swam further than sober fish but both swam less than the salmon who ingested metabolized cocaine surprisingly swam the furthest. This is important because it shows human drug use is screwing up nature. The metabolized cocaine is benzoylecgonine found in human urine and it is being absorbed by the fish. It's super interesting to see how even on dry land humans can change the sea without trying.
jaybone@lemmy.zip · 13 pts · 137d
Are people really using enough cocaine that its impact on the ocean is significant? Like Iโm guessing a lot of people drive a car, which Iโm guessing is a lot worse than cocaine.
cenzorrll@piefed.ca · 11 pts · 137d
Benzoylecgonine is very stable. It can in fact be analyzed in tap water in communities that recycle waste water to determine how much cocaine is being used.
ranzispa@mander.xyz · 3 pts · 136d
Indeed, but it is a fair question to ask: what is the actual concentration in the ocean? I did not read the study, possibly they used a concentration similar to the one encountered in oceans.
Cethin@lemmy.zip · 4 pts · 136d
Seeing as this is about salmon, it's probably more relevant to ask about the concentration in rivers. A river downstream from a reasonable size city likely has a not insignificant level. I assume the ocean is effectively nothing though.
chuckleslord@lemmy.world · 22 pts · 137d
This was actually a really good study. While cocaine certainly fucks them up, it's actually the human-cocaine metabolite that's more impactful! So, ya know, we gotta make sure we're doing waste water treatment so as to not fuck over the fish from the Saturday night, town-wide benders y'all keep having.
Apocalypteroid@anarchist.nexus · 12 pts · 137d
Just won't stop talking utter shit
RaoulDuke85@piefed.social · 2 pts · 137d
And taking shits
Coldgoron@lemmy.zip · 9 pts · 137d
My adhd ass watching as fish get better stimulant medication than I can get. Life is chaos lmao.
village604@adultswim.fan · 10 pts · 137d
Cocaine is a pretty shitty ADHD medication. Meth would be more effective.
CapuccinoCoretto@lemmy.world · 11 pts · 137d
Fun fact time because I'm that guy.
Coke and meth are similar in that they both activate stimulate Dopamine (reward, motivation), Norepinephrine (arousal, alertness) Serotonin (mood, modulation).
However they do it in very different ways:
Cocaine blocks neurotransmitter reuptake from the outside, it stops the neurotransmitter from being released from the synapse causing the area to flood and the synapse to fire more strongly, but still tied to normal stimulation. I.e. your body still produces the transmitter based on normal stimuli, coke just keeps it there longer, stretching the existing signal.
Methamphetamine drives release from the inside. It pushes dopamine out and into the synapse, and has some reuptake inhibition that combines drive the synapses far harder than normal. In contrast to coke, it doesn't stretch existing signals from physiological stimuli, it makes signals regardless of what's going on.
In short, coke blocks the sink's drain. Meth turns on the tap and sorta plugs the drain. Slight advantage to meth here for ADHD. CNS depression that underlies it responds better to meth because the taps don't open enough to begin with. Normal psysiological stimuli isn't enough.
Both in theory could treat ADHD, but meth wins by a longshot because of the speed and stability of its pharmacokinetics. Coke is in and out too fast to give the user the therapeutic window of relief without causing spikes that trigger negatives like addiction or heart problems. Meth is slower and longer lasting. 20-60 mins for coke, ~4 hours for meth. Leveraging extended release (er) formulations pushes meths already superior action (turn on tap) into a daily therapeutic window, while coke is still just behaving like a party drug.
Source: Lots of personal research. ( อกยฐ อส อกยฐ)
village604@adultswim.fan · 6 pts · 137d
I learned the cocaine thing the second time I tried it (first was just a bump at new years that kept me from getting drunk).
My friends were bouncing off the walls having a great time while I sat there and tripled my high score in Snake. I remember thinking, "this is like a shitty Adderall."
Dyskolos@lemmy.zip · 1 pts · 137d
snorts a line....STOP JUDGING MY LIFE CHOICES MAN!
yakko@feddit.uk · 3 pts · 137d
I heard that they were trying to get the WHO to decriminalise coca leaf. Would be great if a cup of tea could replace a controlled substance for ADHD treatment. More research needed ofc but hey, it's hopeful
wurstgulasch3000@feddit.org · 5 pts · 137d
shocked pikachu face
OpenStars@piefed.social · 3 pts · 137d
Gork@sopuli.xyz · 2 pts · 137d
I'm sure salmon would love that when they're swimming upstream back to their spawning pools.
GregorGizeh@lemmy.zip · 3 pts · 137d
Some days ago there was literally an article about this shared around here that says the coked up salmon are swimming for longer and further for their mating season.
Zerush@lemmy.ml · 2 pts · 137d
MajorMajormajormajor@lemmy.ca · 8 pts · 137d
What the fuck?
Ariselas@piefed.ca · 1 pts · 137d
Fuck Yo Couch!
Canuck@sh.itjust.works · 1 pts · 137d
Scientific American | Youtube